Author: Wilson, D.N.
Description: The ribosome is one of the main antibiotic targets in the bacterial cell. Crystal structures of naturally produced antibiotics and their semi-synthetic derivatives bound to ribosomal particles have provided unparalleled insight into their mechanisms of action, and they are also facilitating the design of more effective antibiotics for targeting multidrug-resistant bacteria. In this Review, I discuss the recent structural insights into the mechanism of action of ribosome-targeting antibiotics and the molecular mechanisms of bacterial resistance, in addition to the approaches that are being pursued for the production of improved drugs that inhibit bacterial protein synthesis.
Subject Headings: Anti-Bacterial Agents/pharmacology; Bacteria/drug effects/genetics; Bacterial Proteins/biosynthesis; Drug Resistance, Bacterial; Protein Biosynthesis/drug effects; Protein Conformation; Ribosomes/drug effects/metabolism
Keywords: Ribosome-targeting antibiotics and mechanisms of bacterial resistance
Publication year: 2014
Journal or book title: Nature Reviews. Microbiology
Volume: 12
Issue: 1
Pages: 35-48
Find the full text :Â https://www.nature.com/articles/nrmicro3155
Find more like this one (cited by): https://scholar.google.com/scholar?cites=14108613621771789291&as_sdt=1000005&sciodt=0,16&hl=en
Type: Journal Article
Serial number: 2411