Enantiomerically Pure Tertiary Alcohols by TADDOL-Assisted Additions to Ketones–or How to Make a Grignard Reagent Enantioselective

Author: Weber, B.; Seebach, D.

Description: Nucleophilic additions to ketones with C-C bond formation which selectively produce tertiary stereogenic carbon centers are rare. The authors succeeded in preparing enantioselective Grignard reagents with TADDOL (1), which react with methyl ketones, affording tertiary alcohols with enantiopurities of up to 98% ee (1, Aryl = phenyl, 2-naphthyl).

Subject Headings: Enantiomerically pure tertiary alcohols; Reagent enantioselective; Ketones

Keywords: Enantiomerically Pure Tertiary Alcohols by TADDOL-Assisted Additions to Ketones–or How to Make a Grignard Reagent Enantioselective

Publication year: 1992

Journal or book title: Angewandte Chemie International Edition in English

Volume: 31

Issue: 1

Pages: 84-86

Find the full text : https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.199200841

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Type: Journal Article

Serial number: 2440