Tight junctions as regulators of tissue remodelling

Author: Balda, M.S.; Matter, K.

Description: Formation of tissue barriers by epithelial and endothelial cells requires neighbouring cells to interact via intercellular junctions, which includes tight junctions. Tight junctions form a semipermeable paracellular diffusion barrier and act as signalling hubs that guide cell behaviour and differentiation. Components of tight junctions are also expressed in cell types not forming tight junctions, such as cardiomyocytes, where they associate with facia adherens and/or gap junctions. This review will focus on tight junction proteins and their importance in tissue homeostasis and remodelling with a particular emphasis on what we have learned from animal models and human diseases.

Subject Headings: Animals; Cell Differentiation; Cell Polarity; Cytoplasm/metabolism; Humans; Organ Specificity; Tight Junction Proteins/metabolism; Tight Junctions/metabolism

Keywords: Tight junctions as regulators of tissue remodelling

Publication year: 2016

Journal or book title: Current Opinion in Cell Biology

Volume: 42

Issue:

Pages: 94-101

Find the full text : https://www.sciencedirect.com/science/article/pii/S0955067416300928

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Type: Journal Article

Serial number: 2467