Author: Som, A.; Tezgel, A.O.; Gabriel, G.J.; Tew, G.N.
Description: DIY transduction: Cell‐penetrating peptides (CPPs) efficiently cross the nonpolar biological membrane, but activation by hydrophobic counterions is essential for transport activity. Polymeric mimics of CPPs are coupled with hydrophobic side chains; the “self‐activation” in these species is demonstrated by transport of the fluorescent probe CF out of bilayer vesicles.
Subject Headings: Biological Transport; Biomimetic Materials/chemical synthesis; Cell-Penetrating Peptides/agonists; Guanidine/chemistry; Inhibitory Concentration 50; Norbornanes/chemistry; Polymers/chemical synthesis; Structure-Activity Relationship
Keywords: Self-activation in de novo designed mimics of cell-penetrating peptides
Subject headings:
Publication year: 2011
Journal or book title: Angewandte Chemie (International ed. in English)
Volume: 50
Issue: 27
Pages: 6147-6150
Find the full text : https://www.pse.umass.edu/sites/default/files/tew/documents/Tew-Angew-2011-6147.pdf
Find more like this one (cited by): https://scholar.google.com/scholar?cites=9579047895300840331&as_sdt=1000005&sciodt=0,16&hl=en
Type: Journal Article
Serial number: 2543