Rules of Engagement: The Type VI Secretion System in Vibrio cholerae

Author: Joshi, A.; Kostiuk, B.; Rogers, A.; Teschler, J.; Pukatzki, S.; Yildiz, F.H.

Description: Microbial species often exist in complex communities where they must avoid predation and compete for favorable niches. The type VI secretion system (T6SS) is a contact-dependent bacterial weapon that allows for direct killing of competitors through the translocation of proteinaceous toxins. Vibrio cholerae is a Gram-negative pathogen that can use its T6SS during antagonistic interactions with neighboring prokaryotic and eukaryotic competitors. The T6SS not only promotes V. cholerae’s survival during its aquatic and host life cycles, but also influences its evolution by facilitating horizontal gene transfer. This review details the recent insights regarding the structure and function of the T6SS as well as the diverse signals and regulatory pathways that control its activation in V. cholerae.

Subject Headings: Antibiosis/genetics/physiology; Bacterial Toxins/biosynthesis/metabolism; Cholera/microbiology; Gene Transfer, Horizontal/genetics; Humans; Quorum Sensing/physiology; Type VI Secretion Systems/genetics/metabolism; Vibrio cholerae/genetics/growth & development/pathogenicity; Vibrio cholerae; function; regulation; structure; type VI secretion system (T6SS)

Keywords: Rules of Engagement: The Type VI Secretion System in Vibrio cholerae

Publication year: 2017

Journal or book title: Trends in Microbiology

Volume: 25

Issue: 4

Pages: 267-279

Find the full text :

Find more like this one (cited by):,16&hl=en

Type: Journal Article

Serial number: 2549