Immune regulation by glucocorticoids

Author: Cain, D.W.; Cidlowski, J.A.

Description: Endogenous glucocorticoids are crucial to various physiological processes, including metabolism, development and inflammation. Since 1948, synthetic glucocorticoids have been used to treat various immune-related disorders. The mechanisms that underlie the immunosuppressive properties of these hormones have been intensely scrutinized, and it is widely appreciated that glucocorticoids have pleiotropic effects on the immune system. However, a clear picture of the cellular and molecular basis of glucocorticoid action has remained elusive. In this Review, we distil several decades of intense (and often conflicting) research that defines the interface between the endocrine stress response and the immune system.

Subject Headings: Animals; Glucocorticoids/immunology/pharmacology; Humans; Immune System/drug effects/physiology; Immunosuppressive Agents/immunology/pharmacology; Inflammation/drug therapy

Keywords: Immune regulation by glucocorticoids

Publication year: 2017

Journal or book title: Nature Reviews. Immunology

Volume: 17

Issue: 4

Pages: 233-247

Find the full text :

Find more like this one (cited by):,16&hl=en

Type: Journal Article

Serial number: 2574