Author: Hoover, D.B.; Muth, E.A.; Jacobowitz, D.M.
Description: Acetylcholine (ACh) concentration, choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) were measured in 60 discrete areas dissected from the rat forebrain. All 3 substances were detectable in every region examined. The range for ACh levels was approximately 9-fold, with highest levels in the striatal and mesolimbic area. Wider ranges were found for ChAT and AChE. In addition to not having a uniform distribution, ACh, ChAT and AChE did not always show proportional variations. ACh levels did not appear to relate to the activity of either enzyme in a simple manner. There was a better correlation (r = 0.902) between the activities of ChAT and AChE, with AChE activities always being higher. In some regions, AChE was disproportionately low or high relative to ChAT. In general, the biochemical results presented here are compatible with histochemical studies of AChE. Such measurements in small brain regions should prove valuable in future experiments designed to determine cholinergic function and localize cholinergic pathways.
Subject Headings: Acetylcholine; Choline; Rat brain
Keywords: A mapping of the distribution of acetylcholine, choline acetyltransferase and acetylcholinesterase in discrete areas of rat brain
Publication year: 1978
Journal or book title: Brain Research
Volume: 153
Issue: 2
Pages: 295-306
Find the full text :Â https://www.sciencedirect.com/science/article/pii/0006899378904080
Find more like this one (cited by): https://scholar.google.com/scholar?cites=15462836712503446057&as_sdt=1000005&sciodt=0,16&hl=en
Type: Journal Article
Serial number: 2585