Author: Zambrano, H.; Waggoner, J.J.; Almeida, C.; Rivera, L.; Benjamin, J.Q.; Pinsky, B.A.
Description: Zika virus (ZIKV) and chikungunya virus (CHIKV) cocirculate throughout much of the tropical Western Hemisphere; however, few cases of coinfection with these two pathogens have been reported. Herein, we describe three cases of ZIKV-CHIKV coinfection detected at a single center in Ecuador: a patient who developed symptoms on postoperative day 5 from an orthopedic procedure, a woman who had traveled to Ecuador for fertility treatment, and a woman who was admitted for Guillain-Barre syndrome and had ZIKV and CHIKV detected in serum and cerebrospinal fluid. All cases were diagnosed using a multiplex real-time reverse transcription polymerase chain reaction, and ZIKV viremia was detected as late as 16 days after symptom onset. These cases demonstrate the varied clinical presentation of ZIKV-CHIKV coinfections as well as the importance of multiplexed arboviral testing for these pathogens.
Subject Headings: Adult; Chikungunya Fever/blood/cerebrospinal fluid/complications; Chikungunya virus/genetics; Coinfection/virology; Ecuador; Female; Femoral Fractures/surgery; Fractures, Malunited/surgery; Guillain-Barre Syndrome/cerebrospinal fluid/virology; Humans; Male; Medical Tourism; Middle Aged; Orthopedic Procedures; Postoperative Complications/virology; RNA, Viral/blood; Real-Time Polymerase Chain Reaction; Reproductive Techniques, Assisted; Reverse Transcriptase Polymerase Chain Reaction; Viremia/blood/complications; Zika Virus/genetics; Zika Virus Infection/blood/cerebrospinal fluid/complications
Publication year: 2016
Journal or book title: The American Journal of Tropical Medicine and Hygiene
Volume: 95
Issue: 4
Pages: 894-896
Find the full text: https://www.strategian.com/fulltext/Zambrano2016.pdf
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Type: Journal Article
Serial number: 2587