Emergence and clinical insights into the pathology of Chikungunya virus infection

Author: Jaffar-Bandjee, M.C.; Ramful, D.; Gauzere, B.A.; Hoarau, J.J.; Krejbich-Trotot, P.; Robin, S.; Ribera, A.; Selambarom, J.; Gasque, P.

Description: Major epidemics of Chikungunya have re-emerged with millions of cases worldwide. What was once largely a tropical disease in poorer countries is now recognized as a major global health issue. The disease is perpetuated by the alphavirus Chikungunya, and is transmitted by Aedes mosquitoes. The infection is highly symptomatic, with fever, skin rash and incapacitating arthralgia, which can evolve to chronic arthritis and rheumatism in elderly patients. Mother-to-child transmission, encephalitis, Guillain-Barre syndrome and deaths have been noted. In this article, we will highlight the epidemiological, clinical, virological and immunological aspects of the disease and mention the therapies that have been used during recent epidemics. Novel prevention measures to control the mosquito and a new vaccine are highly warranted.

Subject Headings: Aedes/drug effects/virology; Alphavirus Infections/diagnosis/epidemiology/prevention & control; Animals; Chikungunya virus; Communicable Diseases, Emerging/diagnosis/epidemiology/prevention & control; Encephalitis/pathology; Female; Global Health; Humans; Insect Repellents/administration & dosage; Insect Vectors/drug effects/virology; Male; Pregnancy; Pregnancy Complications, Infectious/diagnosis/epidemiology/prevention & control; Vaccination; Viral Vaccines/administration & dosage

Keywords: Emergence and clinical insights into the pathology of Chikungunya virus infection

Publication year: 2010

Journal or book title: Expert Review of Anti-Infective Therapy

Volume: 8

Issue: 9

Pages: 987-996

Find the full text : https://www.tandfonline.com/doi/abs/10.1586/eri.10.92

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Type: Journal Article

Serial number: 2588