Clinical efficacy of the 5-HT3 antagonist ondansetron in alcohol abuse and dependence

Author: Sellers, E.M.; Toneatto, T.; Romach, M.K.; Somer, G.R.; Sobell, L.C.; Sobell, M.B.

Description: Medications that act on the serotonergic system have been found to be of benefit in the treatment of alcohol-dependent individuals. In a randomized, placebo-controlled study, the efficacy of 6 weeks of ondansetron, a 5-HT3 antagonist (0.25 mg bid or 2.0 mg bid), in the treatment of 71 nonseverely alcohol-dependent males was tested. The results showed reduction of drinking differences were steadily increasing toward the end of the treatment period approached significance at week 7 in the 0.25 mg group (p = 0.06). Twice as many patients in this group showed > or = 2 standard deviations decrease in drinking compared with the other groups. When patients drinking > 10 drinks/drinking day at baseline (n = 11) were excluded from the analysis, significant group differences were found at both treatment and follow-up, with the lower ondansetron dose producing the greatest reduction from baseline (i.e., 2.8 standard drinks; -35% compared with baseline and -21% compared with placebo; p < 0.02-0.001). Within this group, there was an almost 4-fold greater number of patients showing a clinically meaningful decrease in drinking. Lower baseline drinking and higher level of education were significant and strong predictors of drinking reduction during treatment. Ondansetron was very well tolerated; hence, further long-term studies with 5-HT3 antagonists alone or in combination with other treatment components may offer promise for treatment of alcoholism.

Subject Headings: Adult; Alcoholism/rehabilitation; Dose-Response Relationship, Drug; Double-Blind Method; Follow-Up Studies; Humans; Male; Middle Aged; Ondansetron/administration & dosage/adverse effects; Receptors, Serotonin/classification/drug effects

Keywords: Clinical efficacy of the 5-HT3 antagonist ondansetron in alcohol abuse and dependence

Publication year: 1994

Journal or book title: Alcoholism, Clinical and Experimental Research

Volume: 18

Issue: 4

Pages: 879-885

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Type: Journal Article

Serial number: 2612