Author: Routier, S.; Saugé, L.; Ayerbe, N.; Coudert, G.; Mérour, J.-Y.
Description: A new mild method to remove N-tert-butyloxycarbonyl groups using TBAF in refluxing THF is reported. In all cases, the corresponding N-free products are obtained in good yields. The reactions are selective for acid- and base-sensitive groups, such as tert-butyl and alkyl esters, aldehydes.
Subject Headings: TBAF; N-Boc; THF
Keywords: A mild and selective method for N-Boc deprotection
Publication year: 2002
Journal or book title: Tetrahedron Letters
Volume: 43
Issue: 4
Pages: 589-591
Find the full text : https://www.sciencedirect.com/science/article/pii/S0040403901022250
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Type: Journal Article
Serial number: 2685