Author: Lutter, M.; Sakata, I.; Osborne-Lawrence, S.; Rovinsky, S.A.; Anderson, J.G.; Jung, S.; Birnbaum, S.; Yanagisawa, M.; Elmquist, J.K.; Nestler, E.J.; Zigman, J.M.
Description: We found that increasing ghrelin levels, through subcutaneous injections or calorie restriction, produced anxiolytic- and antidepressant-like responses in the elevated plus maze and forced swim test. Moreover, chronic social defeat stress, a rodent model of depression, persistently increased ghrelin levels, whereas growth hormone secretagogue receptor (Ghsr) null mice showed increased deleterious effects of chronic defeat. Together, these findings demonstrate a previously unknown function for ghrelin in defending against depressive-like symptoms of chronic stress.
Subject Headings: Analysis of Variance; Animals; Behavior, Animal; Caloric Restriction/methods; Depression/etiology/prevention & control; Disease Models, Animal; Eating/drug effects/genetics; Enzyme-Linked Immunosorbent Assay; Freezing Reaction, Cataleptic/drug effects/physiology; Ghrelin/administration & dosage/metabolism; Maze Learning/physiology; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity/drug effects/genetics; Orexin Receptors; Reaction Time/physiology; Receptors, G-Protein-Coupled/deficiency; Receptors, Ghrelin/deficiency; Receptors, Neuropeptide/deficiency; Stress, Psychological/complications/genetics; Swimming; Time Factors
Publication year: 2008
Journal or book title: Nature Neuroscience
Volume: 11
Issue: 7
Pages: 752-753
Find the full text: https://www.strategian.com/fulltext/Lutter2008.pdf
Find more like this one (cited by): https://scholar.google.com/scholar?cites=10715476039135694634&as_sdt=1000005&sciodt=0,16&hl=en
Type: Journal Article
Serial number: 2750