Author: Rasmussen, T.B.; Givskov, M.
Description: Quorum-sensing (QS) signalling systems of pathogens are central regulators for the expression of virulence factors and represent highly attractive targets for the development of novel therapeutics. In Pseudomonas aeruginosa, QS systems are also involved in elevated antibiotic tolerance of biofilms as well as elevated tolerance to the activity of the innate immune system. Gram-negative bacteria commonly use N-acyl homoserine lactones (AHL) as QS signal molecules. The use of signal molecule based drugs to attenuate bacterial pathogenecity rather than bacterial growth is attractive for several reasons, particularly considering the emergence of increasingly antibiotic-resistant bacteria. Compounds capable of this type of interference have been termed anti-pathogenic drugs. A large variety of synthetic AHL analogues and natural products libraries have been screened and a number of QS inhibitors (QSI) have been identified. Promising QSI compounds have been shown to make biofilms more susceptible to antimicrobial treatments, and are capable of reducing mortality and virulence as well as promoting clearance of bacteria in experimental animal models of infection.
Subject Headings: 4-Butyrolactone/analogs & derivatives/antagonists & inhibitors/metabolism/physiology; Animals; Anti-Bacterial Agents/pharmacology; Bacterial Proteins/metabolism/pharmacology; Biofilms/drug effects; Cell Communication/drug effects; Ligases/antagonists & inhibitors; Metalloendopeptidases/metabolism; Neutrophils/physiology; Pseudomonas aeruginosa/drug effects/pathogenicity/physiology; Repressor Proteins/physiology; Trans-Activators/physiology; Virulence
Keywords: Quorum-sensing inhibitors as anti-pathogenic drugs
Publication year: 2006
Journal or book title: International Journal of Medical Microbiology : IJMM
Volume: 296
Issue: 2-3
Pages: 149-161
Find the full text :Â https://www.sciencedirect.com/science/article/pii/S1438422106000786
Find more like this one (cited by): https://scholar.google.com/scholar?cites=11968199286575200768&as_sdt=1000005&sciodt=0,16&hl=en
Type: Journal Article
Serial number: 2806