Author: Neumann, J.J.; Rakshit, S.; Droge, T.; Wurtz, S.; Glorius, F.
Description: The direct Pd-catalyzed oxidative coupling of two C-H-bonds within N-aryl-enamines 1 allows the efficient formation of differently substituted indoles 2. In this cross-dehydrogenative coupling, many different functional groups are tolerated and the starting material N-aryl-enamines 1 can be easily prepared in one step from commercially available anilines. In addition, the whole sequence can also be run in a one-pot fashion. Optimization data, mechanistic insight, substrate scope, and applications are reported in this full paper.
Subject Headings: Amines/chemistry; Aniline Compounds/chemistry; Catalysis; Cyclization; Indoles/chemical synthesis/chemistry; Molecular Structure; Oxidation-Reduction; Palladium/chemistry
Keywords: Amines/chemistry; Aniline Compounds/chemistry; Catalysis; Cyclization; Indoles/chemical synthesis/chemistry; Molecular Structure; Oxidation-Reduction; Palladium/chemistry
Publication year: 2011
Journal or book title: Chemistry (Weinheim an der Bergstrasse, Germany)
Volume: 17
Issue: 26
Pages: 7298-7303
Find the full text : https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/chem.201100631
Find more like this one (cited by): https://scholar.google.com/scholar?cites=17885248330805491899&as_sdt=1000005&sciodt=0,16&hl=en
Type: Journal Article
Serial number: 2814