Author: Smith, B.E.; Roder, P.B.; Zhou, X.; Pauzauskie, P.J.
Description: Recently, the use of nanoscale materials has attracted considerable attention with the aim of designing personalized therapeutic approaches that can enhance both spatial and temporal control over drug release, permeability, and uptake. Potential benefits to patients include the reduction of overall drug dosages, enabling the parallel delivery of different pharmaceuticals, and the possibility of enabling additional functionalities such as hyperthermia or deep-tissue imaging (LIF, PET, etc.) that complement and extend the efficacy of traditional chemotherapy and surgery. This mini-review is focused on an emerging class of nanometer-scale materials that can be used both to heat malignant tissue to reduce angiogenesis and DNA-repair while simultaneously offering complementary imaging capabilities based on radioemission, optical fluorescence, magnetic resonance, and photoacoustic methods.
Subject Headings: Animals; Diagnostic Imaging; Drug Carriers/chemistry; Humans; Metal Nanoparticles/chemistry; Nanostructures/chemistry; Nanotubes, Carbon/chemistry; Neoplasms/diagnosis/diagnostic imaging/drug therapy; Photochemotherapy; Photosensitizing Agents/chemistry/therapeutic use; Radiography; Semiconductors; Theranostic Nanomedicine
Keywords: Nanoscale materials for hyperthermal theranostics
Publication year: 2015
Journal or book title: Nanoscale
Volume: 7
Issue: 16
Pages: 7115-7126
Find the full text : https://pubs.rsc.org/en/content/getauthorversionpdf/c4nr06164k
Find more like this one (cited by): https://scholar.google.com/scholar?cites=5809247592721783677&as_sdt=1000005&sciodt=0,16&hl=en
Type: Journal Article
Serial number: 2819