CuI-Catalyzed Alkyne-Azide “Click” Cycloadditions from a Mechanistic and Synthetic Perspective

Author: Bock, V.D.; Hiemstra, H.; van Maarseveen, J.H.

Description: CuI-catalyzed alkyne–azide cycloaddition provides 1,4-disubstituted 1,2,3-triazoles with such efficiency and scope that the transformation has been described as “click” chemistry. An overview of the mechanism of this remarkable reaction is presented as a means to explain the myriad of experimental results, particularly the various methods of catalyst generation, solvent and substrate effects, and choice of base or ligand. Both solution-phase and solid-phase results are comprehensively examined. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)

Subject Headings: Click chemistry; Cycloaddition; Heterocycles; Molecular diversity; Azides

Keywords: CuI-Catalyzed Alkyne-Azide “Click” Cycloadditions from a Mechanistic and Synthetic Perspective

Publication year: 2006

Journal or book title: European Journal of Organic Chemistry

Volume: 2006

Issue: 1

Pages: 51-68

Find the full text : https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.200500483

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Type: Journal Article

Serial number: 2848