Author: Sharma, R.; Yang, Y.; Sharma, A.; Awasthi, S.; Awasthi, Y.C.
Description: It has been known that glutathione S-transferases (GSTs) can reduce lipid hydroperoxides through their Se-independent glutathione peroxidase activity and that these enzymes can also detoxify lipid peroxidation end products such as 4-hydroxynonenal (4-HNE). In this article, recent studies suggesting that the Alpha class GSTs provide a formidable defense against oxidative stress are critically evaluated and the role of these enzymes in the regulation of oxidative stress-mediated signaling is reviewed. Available evidence from earlier studies together with results of recent studies in our laboratories strongly suggests that lipid peroxidation products, particularly hydroperoxides and 4-HNE, are involved in the mechanisms of stress-mediated signaling and that it can be modulated by the Alpha class GSTs through the regulation of the intracellular concentrations of 4-HNE.
Subject Headings: Aldehydes/metabolism; Animals; Antioxidants/metabolism; Apoptosis/physiology; Gene Expression Regulation; Glutathione Transferase/metabolism; Humans; K562 Cells; Lipid Peroxidation; Oxidants/toxicity; Oxidative Stress; Signal Transduction/physiology; Ultraviolet Rays
Publication year: 2004
Journal or book title: Antioxidants & Redox Signaling
Volume: 6
Issue: 2
Pages: 289-300
Find the full text : https://eagle.fish.washington.edu/trilobite/notebooks/steven/eagle.fish.washington.edu/oyster/Dissertation/dissertation%20drafts/articles/sharma%20et%20al%202004.pdf
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Type: Journal Article
Serial number: 2952