Author: Ellis, H. M.; Horvitz, H. R.
Description: The wild-type functions of the genes ced-3 and ced-4 are required for the initiation of programmed cell deaths in the nematode Caenorhabditis elegans. The reduction or loss of ced-3 or ced-4 function results in a transformation in the fates of cells that normally die; in ced-3 or ced-4 mutants, such cells instead survive and differentiate, adopting fates that in the wild type and associated with other cells. ced-3 and ced-4 mutants appear grossly normal in morphology and behavior, indicating that programmed cell death is not an essential aspect of nematode development. The genes ced-3 and ced-4 define the first known step of a developmental pathway for programmed cell death, suggesting that these genes may be involved in determining which cells die during C. elegans development.
Subject headings: Alleles; Animals; Caenorhabditis elegans; Cell Differentiation; Cell Division; Cell Survival; Male; Mutation; Phenotype, Receptors; Dopamine, Receptors; Serotonin; C elegans
Publication year: 1986
Journal or book title: Cell
Volume: 44
Issue: 6
Pages: 817-829
Find the full text: https://www.its.caltech.edu/~bich113/PDFs/Section%20papers/Ellis_Horowitz_1986.pdf
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Serial number: 3665