The Mre11 complex: at the crossroads of DNA repair and checkpoint signalling

Author: D’Amours, D.; Jackson, S.P.

Description: The Mre11 complex is a multisubunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2. Mutations in the genes that encode components of this complex result in DNA- damage sensitivity, genomic instability, telomere shortening and aberrant meiosis. The molecular defect that underlies these phenotypes has long been thought to be related to a DNA repair deficiency. However, recent studies have uncovered functions for the Mre11 complex in checkpoint signalling and DNA replication.

Subject Headings: Animals; DNA Repair/genetics/physiology; DNA, Fungal/physiology; DNA-Binding Proteins; Deoxyribonucleases/physiology; Endodeoxyribonucleases/physiology; Exodeoxyribonucleases/physiology; Fungal Proteins/physiology; Genes, cdc/physiology; Humans; Macromolecular Substances; Nuclear Proteins/physiology; Phosphorylation; Saccharomyces cerevisiae/physiology; Saccharomyces cerevisiae Proteins; Signal Transduction/physiology; Telomere/physiology; Nuclease

Publication year: 2002

Journal or book title: Nature Reviews. Molecular Cell Biology

Volume: 3

Issue: 5

Pages: 317-327

Find the full text :

Find more like this one (cited by):,16&hl=en

Type: Journal Article

Serial number: 2563