Author: D’Amours, D.; Jackson, S.P.
Description: The Mre11 complex is a multisubunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2. Mutations in the genes that encode components of this complex result in DNA- damage sensitivity, genomic instability, telomere shortening and aberrant meiosis. The molecular defect that underlies these phenotypes has long been thought to be related to a DNA repair deficiency. However, recent studies have uncovered functions for the Mre11 complex in checkpoint signalling and DNA replication.
Subject Headings: Animals; DNA Repair/genetics/physiology; DNA, Fungal/physiology; DNA-Binding Proteins; Deoxyribonucleases/physiology; Endodeoxyribonucleases/physiology; Exodeoxyribonucleases/physiology; Fungal Proteins/physiology; Genes, cdc/physiology; Humans; Macromolecular Substances; Nuclear Proteins/physiology; Phosphorylation; Saccharomyces cerevisiae/physiology; Saccharomyces cerevisiae Proteins; Signal Transduction/physiology; Telomere/physiology; Nuclease
Publication year: 2002
Journal or book title: Nature Reviews. Molecular Cell Biology
Volume: 3
Issue: 5
Pages: 317-327
Find the full text : https://www.nature.com/articles/nrm805
Find more like this one (cited by): https://scholar.google.com/scholar?cites=4400771801927013740&as_sdt=1000005&sciodt=0,16&hl=en
Type: Journal Article
Serial number: 2563