Author: Crestani, F.; Lorez, M.; Baer, K.; Essrich, C.; Benke, D.; Laurent, J. P.; Belzung, C.; Fritschy, J. M.; Luscher, B.; Mohler, H.
Description: Patients with panic disorders show a deficit of GABAA receptors in the hippocampus, parahippocampus and orbitofrontal cortex. Synaptic clustering of GABAA receptors in mice heterozygous for the gamma2 subunit was reduced, mainly in hippocampus and cerebral cortex. The gamma2 +/- mice showed enhanced behavioral inhibition toward natural aversive stimuli and heightened responsiveness in trace fear conditioning and ambiguous cue discrimination learning. Implicit and spatial memory as well as long-term potentiation in hippocampus were unchanged. Thus gamma2 +/- mice represent a model of anxiety characterized by harm avoidance behavior and an explicit memory bias for threat cues, resulting in heightened sensitivity to negative associations. This model implicates GABAA-receptor dysfunction in patients as a causal predisposition to anxiety disorders.
Subject headings: Animals; Anxiety; Anxiety Disorders; Avoidance Learning; Conditioning, Operant; Cues; Fear; Heterozygote; Hippocampus; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Neurons; Patch-Clamp Techniques; Receptors; GABA-A; Gamma-Aminobutyric Acid
Publication year: 1999
Journal or book title: Nature Neuroscience
Volume: 2
Issue: 9
Pages: 833-839
Find the full text: https://www.nature.com/articles/nn0999_833
Find more like this one (cited by): https://scholar.google.com/scholar?cites=7361920147965667332&as_sdt=1000005&sciodt=0,16&hl=en
Serial number: 3810