Active targeting of cancer cells using folic acid-conjugated platinum nanoparticles

Author: Teow, Yiwei; Valiyaveettil, Suresh

Description: Interaction of nanoparticles with human cells is an interesting topic for understanding toxicity and developing potential drug candidates. Water soluble platinum nanoparticles were synthesized via reduction of hexachloroplatinic acid using sodium borohydride in the presence of capping agents. The bioactivity of folic acid and poly(vinyl pyrrolidone) capped platinum nanoparticles (Pt-nps) has been investigated using commercially available cell lines. In the cell viability experiments, PVP-capped nanoparticles were found to be less toxic (> 80% viability), whereas, folic acid-capped platinum nanoparticles showed a reduced viability down to 24% after 72 h of exposure at a concentration of 100 g ml(-1) for MCF7 breast cancer cells. Such toxicity, combined with the possibility to incorporate functional organic molecules as capping agents, can be used for developing new drug candidates.

Subject headings: Antineoplastic Agents; Apoptosis; Cell Line; Tumor; Drug Carriers; Folic Acid; Humans; Metal Nanoparticles; Microscopy, Confocal; Platinum; Povidone

Publication year: 2010

Journal or book title: Nanoscale

Volume: 2

Issue: 12

Pages: 2607-2613

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Serial number: 3855