Bacteriophage resistance mechanisms

Author: Labrie, Simon J.; Samson, Julie E.; Moineau, Sylvain

Description: Phages are now acknowledged as the most abundant microorganisms on the planet and are also possibly the most diversified. This diversity is mostly driven by their dynamic adaptation when facing selective pressure such as phage resistance mechanisms, which are widespread in bacterial hosts. When infecting bacterial cells, phages face a range of antiviral mechanisms, and they have evolved multiple tactics to avoid, circumvent or subvert these mechanisms in order to thrive in most environments. In this Review, we highlight the most important antiviral mechanisms of bacteria as well as the counter-attacks used by phages to evade these systems.

Subject headings: Adsorption; Bacteria; Bacterial Physiological Phenomena; Bacteriophages; DNA Restriction-Modification Enzymes; DNA, Viral; Extracellular Matrix; Models, Biological; Receptors, Virus; Virus Attachment; Virus Internalization

Publication year: 2010

Journal or book title: Nature Reviews. Microbiology

Volume: 8

Issue: 5

Pages: 317-327

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Serial number: 3891