Author: Tang, V.; Poon, W. S. & Kwan, P.
Description: To investigate the effectiveness of mindfulness-based therapy (MT) and social support (SS) in patients with drug-resistant epilepsy. We performed an assessor-blinded randomized control trial. Sixty patients with drug-resistant epilepsy were randomly allocated to MT or SS (30 per group). Each group received 4 biweekly intervention sessions. The primary outcome was the change in the total score of the Patient-Weighted Quality of Life in Epilepsy Inventory (QOLIE-31-P). Secondary outcomes included seizure frequency, mood symptoms, and neurocognitive functions. The assessors were blinded to the patient’s intervention grouping. Results were analyzed using general linear model with repeated measure. Following intervention, both the MT (n=30) and SS (n=30) groups had an improved total QOLIE-31-P, with an improvement of +6.23 for MT (95% confidence interval [CI] +4.22 to +10.40) and +3.30 for SS (95% CI +1.03 to +5.58). Significantly, more patients in the MT group had a clinically important improvement in QOLIE-31-P (+11.8 or above) compared to those who received SS (11 patients vs 4 patients). Significantly greater reduction in depressive and anxiety symptoms, seizure frequency, and improvement in delayed memory was observed in the MT group compared with the SS group. We found benefits of short-term psychotherapy on patients with drug-resistant epilepsy. Mindfulness therapy was associated with greater benefits than SS alone in quality of life, mood, seizure frequency, and verbal memory. This study provides Class II evidence that mindfulness-based therapy significantly improves quality of life in patients with drug-resistant epilepsy.
Subject headings: Adult; Drug Resistance; Epilepsy, therapy; Female; Humans; Male; Middle Aged; Mindfulness, methods; Psychotherapy, Group, methods; Quality of Life; Single-Blind Method; Social Support; Treatment Outcome
Publication year: 2015
Journal or book title: Neurology
Volume: 85
Issue: 13
Pages: 1100-1107
Find the full text: https://n.neurology.org/content/85/13/1100.short
Find more like this one (cited by): https://scholar.google.com/scholar?cites=12457164673920616364&as_sdt=5,26&sciodt=0,26&hl=en
Type: Journal article
Serial number: 3052