The human CENP-A centromeric nucleosome-associated complex

Author: Foltz, D.R.; Jansen, L.E.T.; Black, B.E.; Bailey, A.O.; Yates, J.R. 3rd; Cleveland, D.W. Description: The basic element for chromosome inheritance, the centromere, is epigenetically determined in mammals. The prime candidate for specifying centromere identity is the array of nucleosomes assembled with CENP-A, the centromere-specific histone H3 variant. Here, we show that CENP-A nucleosomes directly recruit a proximal CENP-A nucleosome associated complex (NAC) comprised of three new human centromere proteins (CENP-M, CENP-N and CENP-T), along with CENP-U(50), CENP-C and CENP-H. Assembly of the CENP-A NAC at centromeres is dependent on…

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Cu(I)-catalyzed one-pot synthesis of 1,4-disubstituted 1,2,3-triazoles via nucleophilic displacement and 1,3-dipolar cycloaddition

Author: Sreedhar, B.; Reddy, P.S.; Kumar, N.S. Description: An efficient method is described for the regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles in high yields from a variety of Baylis–Hillman acetates and terminal alkynes with sodium azide using CuI as a catalyst, in either water or polyethylene glycol (PEG). This procedure is operationally simple and environmentally benign. Polyethylene glycol (PEG) serves as an efficient reusable solvent with higher efficiency. Subject Headings: 1,4-Disubstituted 1,2,3-triazoles; 1,3-Dipolar cycloaddition; PEG; Water; CuI Publication year: 2006 Journal or book title: Tetrahedron Letters Volume: 47 Issue: 18 Pages:…

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A novel approach for the synthesis of the peripheral benzodiazepine receptor ligand, PK11195

Author: Stevenson, L.; Pimlott, S.L.; Sutherland, A. Description: A new synthesis of the peripheral benzodiazepine receptor ligand, PK11195 has been developed in only six-steps using a Heck-type reaction and a Suzuki coupling to effect the key transformations. The flexibility of this new approach is demonstrated by the synthesis of an iodo-analogue of PK11195 prepared from the corresponding bromide using a copper catalysed aromatic Finkelstein reaction. Subject headings: Finkelstein reaction; Receptor ligand; PK11195 Publication year: 2007 Journal or book title: Tetrahedron Letters Volume: 48 Issue: 40 Pages: 7137-7139 Find the full…

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Microwave-assisted reactions of nitroheterocycles with dienes. Diels-Alder and tandem hetero Diels-Alder/[3,3] sigmatropic shift

Author: Victoria Gómez, M.; Aranda, A.I.; Moreno, A.; Cossío, F.P.; de Cózar, A.; Díaz-Ortiz, Á.; de la Hoz, A.; Prieto, P. Description: Diels-Alder cycloaddition of 3-nitro-1-(p-toluenesulfonyl)indole 1 with dienes 2-6 under microwave irradiation in solvent-free conditions gave carbazole derivatives after elimination of the nitro group and in situ aromatization. While 3-nitro-1-(p-toluenesulfonyl)pyrrole 11 afforded indole derivatives, 4-nitro-1-(p-toluenesulfonyl)pyrazole 13 with cyclohexadiene 2 did not afford the expected cycloadduct but instead gave 1-cyclohexen-2-ylpyrazole 16. This process occurred by hydrolysis of the 1-(p-toluenesulfonyl) group, protonation of the diene and nucleophilic addition of the pyrazolate…

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Cross-metathesis of allyl halides with olefins bearing amide and ester groups

Author: Yun, J.I.; Kim, H.R.; Kim, S.K.; Kim, D.; Lee, J. Description: An investigation was conducted to determine whether the cross-metathesis (CM) of allyl halides tolerates amide groups. The results show that the ruthenium-based complexes I–III serve as poor catalysts for the CM of allyl halides with olefins that contain an N,N-dimethylamide group. In contrast, the Grubbs–Hoveyda–Blechert second generation catalyst (III) efficiently promotes these processes with olefins bearing a Weinreb amide group. Lastly, a reinvestigation of the ester group tolerance of the allyl halide CM with unsaturated esters demonstrated that…

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Comparative Analysis of National Policies for Electric Vehicle Uptake Using Econometric Models

Author: Yao, J.; Xiong, S.; Ma, X. Description: As electric vehicles (EVs) have been widely discussed as a promising way to mitigate the effect of climate change, various policies have been implemented across the world to promote the uptake of EVs. Policymakers also paid attention to the density of public charging points. In this paper, we examined the impact of policies on EV markets in the post subsidy era with multiple linear regression analysis using panel data on 13 countries from 2015 to 2018. Five of the independent variables showed…

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Technology Development of Electric Vehicles: A Review

Author: Sun, X.; Li, Z.; Wang, X.; Li, C. Description: To reduce the dependence on oil and environmental pollution, the development of electric vehicles has been accelerated in many countries. The implementation of EVs, especially battery electric vehicles, is considered a solution to the energy crisis and environmental issues. This paper provides a comprehensive review of the technical development of EVs and emerging technologies for their future application. Key technologies regarding batteries, charging technology, electric motors and control, and charging infrastructure of EVs are summarized. This paper also highlights the…

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Are Existing Battery Electric Vehicles Adoption Studies Able to Inform Policy? A Review for Policymakers

Author: Song, R.; Potoglou, D. Description: Accelerating the adoption of electric vehicles provides a rare historic opportunity for reducing the dependence on fossil fuel and decarbonising road networks in the field of transport. Many countries have introduced various policy packages on both national and local levels to encourage electric vehicle adoption, but their market shares remain low. For better understanding the reasons behind this evidence, exploring the determinants that influence consumers’ adoption intentions is significant. Previous literature reviews have made clear and elaborated syntheses of influential factors; however, a summary…

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Technological development of key domains in electric vehicles: Improvement rates, technology trajectories and key assignees

Author: Feng, S.; Magee, C.L. Description: Technology innovation in electric vehicles is of significant interest to researchers, companies and policy-makers of many countries. Electric vehicles integrate various kinds of distinct technologies and decomposing the overall electric vehicle field into several key domains allows determination of more detailed, valuable information. To provide both broader and more detailed information about technology development in the EV field, unlike most previous studies on electric vehicle innovation which analyzed this field as a whole, this research decomposed the electric vehicle field into domains, which are…

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ReCl(CO)5-catalyzed cyclocondensation of phenols with 2-methyl-3-butyn-2-ol to afford 2,2-dimethyl-2H-chromenes

Author: Zeng, H.; Ju, J.; Hua, R. Description: A direct one-pot route for the synthesis of 2,2-dimethyl-2H-chromenes by Re(CO)5Cl-catalyzed cyclocondensation of phenols with 2-methyl-3-butyn-2-ol has been developed. The easy availability of starting materials, mild reaction conditions, high atom-efficiency, and the use of a recoverable catalyst are advantages of this procedure. Subject headings: Condensation; 2,2-Dimethyl-2H-chromenes; 2-Methyl-3-butyn-2-ol; Phenol; Rhenium Publication year: 2011 Journal or book title: Tetrahedron Letters Volume: 52 Issue: 30 Pages: 3926-3928 Find the full text : http://www.sciencedirect.com/science/article/pii/S0040403911008525 Find more like this one (cited by): https://scholar.google.com/scholar?cites=12171420446194572858&as_sdt=1000005&sciodt=0,16&hl=en Type: Journal Article Serial…

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