A hospital outbreak of Serratia marcescens associated with ultrasonic nebulizers

Ringrose, R.E., McKown, B., Felton, F.G., Barclay, B.O., Muchmore, H.G., Rhoades, E.R. (1968) Annals of Internal Medicine, 69(4), 719-729 A sevenfold increase in the frequency of isolation of Serratia marcescens was noted during a 2-month period. Nineteen patients were involved, and the majority of these patients acquired the organism during hospitalization. Two of the patients had signs and symptoms of definite infection. Seven others probably had infections, and the remainder appeared to have had simple colonization. All 19 patients had associated medical conditions or prior therapy. S. marcescens should be…

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LadS is a calcium-responsive kinase that induces acute-to-chronic virulence switch in Pseudomonas aeruginosa

Broder, U.N.; Jaeger, T.; Jenal, U. (2016) Nature Microbiology, 2, 16184 Virulence of pathogenic bacteria is a tightly controlled process to facilitate invasion and survival in host tissues. Although pathways controlling virulence have been defined in detail, signals modulating these processes are poorly understood. The opportunistic pathogen Pseudomonas aeruginosa causes acute and chronic infections in humans. Disease progression is typically associated with a loss of acute virulence and the emergence of biofilms and chronic behavior. The acute-to-chronic switch is governed by the global Gac/Rsm pathway. Using a newly developed acute-chronic…

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