Conjugate addition of indoles and thiols with electron-deficient olefins catalyzed by Bi(OTf)3

Alam, M.M., Varala, R., Adapa, S.R. (2003) Tetrahedron Letters, 44(27), 5115-5119 Conjugate addition of indoles and thiols with a variety of electron-deficient olefins mediated by a catalytic amount of Bi(OTf)3 at ambient temperature to afford the corresponding Michael adducts in good to excellent yields with high selectivity is reported. Subject Headings: Bi(OTf)3; indoles; thiols; alpha, Beta-unsaturated compounds; addition reactions Find the full text: https://www.sciencedirect.com/science/article/pii/S004040390301089X Find more like this one (cited by): https://scholar.google.com/scholar?cites=11716101828703031418&as_sdt=1000005&sciodt=0,16&hl=en Type: Journal Article Serial number: 2843

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Perinatal exposure to genistein alters reproductive development and aggressive behavior in male mice

Wisniewski, A.B., Cernetich, A., Gearhart, J.P., Klein, S.L. (2005) Physiology & Behavior, 84(2), 327-334 Exposure to endocrine disrupting chemicals adversely affects reproductive development and behavior in males. The goal of this study was to determine if exposure to genistein, an isoflavone found in soy, during early periods of sex differentiation alters reproductive development and behavior in male mice. Female C57BL/6 mice were fed a phytoestrogen-free diet supplemented with 0, 5 or 300 mg/kg of genistein throughout gestation and lactation. Anogenital distance (AGD) and body mass of male offspring was measured…

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Comparative teratogenicity of chlorpyrifos and malathion on Xenopus laevis development

Bonfanti, P., Colombo, A., Orsi, F., Nizzetto, I., Andrioletti, M., Bacchetta, R., Mantecca, P., Fascio, U., Vailati, G., Vismara, C. (2004) Aquatic Toxicology, 70(3), 189-200 The embryotoxic potential of chlorpyrifos (CPF) and malathion (MTN), two organophosphorus insecticides (OPs), was evaluated by modified Frog Embryo Teratogenesis Assay-Xenopus (FETAX). CPF and MTN were not embryolethal even at the highest concentration tested (6000 microg/l), but both exhibited a powerful teratogenicity. The probit analysis of malformed larva percentages showed a TC(50) of 161.54mug/l for CPF, and a TC(50) of 2394.01 microg/l for MTN. Therefore,…

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Effects of malathion on survival, growth, development, and equilibrium posture of bullfrog tadpoles (Rana catesbeiana)

Fordham, C.L., Tessari, J.D., Ramsdell, H.S., Keefe, T.J. (2001) Environmental Toxicology and Chemistry, 20(1), 179-184 Bullfrog (Rana catesbeiana) tadpoles were exposed to malathion in water in a 28-d static renewal test. The effects of malathion on survival, growth, development, and loss of equilibrium posture were determined. Survival was significantly decreased at malathion concentrations of 2,500 micrograms/L and higher. Development of tadpoles was delayed significantly by malathion exposure as indicated by a dose-related decrease in developmental stage over time. Development of tadpoles in the 1,000-microgram/L and higher treatment groups was significantly…

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Pesticides and amphibian population declines in California, USA

Sparling, D.W., Fellers, G.M., McConnell, L.L. (2001) Environmental Toxicology and Chemistry, 20(7), 1591-1595 Several species of anuran amphibians have undergone drastic population declines in the western United States over the last 10 to 15 years. In California, the most severe declines are in the Sierra Mountains east of the Central Valley and downwind of the intensely agricultural San Joaquin Valley. In contrast, coastal and more northern populations across from the less agrarian Sacramento Valley are stable or declining less precipitously. In this article, we provide evidence that pesticides are instrumental…

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Declining Downwind: Amphibian Population Declines in California and Historical Pesticide Use

Davidson, C. (2004) Ecological Applications, 14(6), 1892-1902 Pesticides have long been proposed as a possible cause of amphibian population declines, but due to a number of challenges there has been relatively little ecotoxicological research on pesticides and declines in natural populations. My study examines the association between the spatial patterns of declines for five California amphibian species and historical patterns of pesticide use in California from 1974 to 1991 based on Department of Pesticide Regulation records. Information on declines was derived from maps of historical sites and current population status…

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Soil microbial diversity and community structure under wheat as influenced by tillage and crop rotation

Lupwayi, N.Z., Rice, W.A., Clayton, G.W. (1998) Soil Biology and Biochemistry, 30(13), 1733-1741 Soil microbial diversity is important to sustainable agriculture because microbes mediate many processes that support agricultural production. The BIOLOG system for detection of specific patterns of substrate utilization by bacteria was used to investigate the effects of tillage and crop rotation on the diversity and community structure of soil bacteria. In each of 2 yr, soil was sampled (0-7.5 cm) in the wheat phase of different cropping rotations which had been established under zero tillage or conventional…

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Gender-specific neuroimmunoendocrine aging in a triple-transgenic 3xTg-AD mouse model for Alzheimer’s disease and its relation with longevity

Gimenez-Llort, L., Arranz, L., Mate, I., De la Fuente, M. (2008) Neuroimmunomodulation, 15(4-6), 331-343 In the present work, we briefly review the evidence on the key role played by the neuroimmunoendocrine network in the etiopathogenesis of Alzheimer’s disease (AD) and provide new behavioral, immune and endocrinological data obtained on old male and female triple-transgenic 3xTg-AD mice harboring PS1(M146V), APP(Swe) and tau(P301L) transgenes in contrast to wild-type animals. The results indicate that several aspects of the impairment of the neuroimmunoendocrine network that occurs with aging are more evident in the 3xTg-AD…

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A hospital outbreak of Serratia marcescens associated with ultrasonic nebulizers

Ringrose, R.E., McKown, B., Felton, F.G., Barclay, B.O., Muchmore, H.G., Rhoades, E.R. (1968) Annals of Internal Medicine, 69(4), 719-729 A sevenfold increase in the frequency of isolation of Serratia marcescens was noted during a 2-month period. Nineteen patients were involved, and the majority of these patients acquired the organism during hospitalization. Two of the patients had signs and symptoms of definite infection. Seven others probably had infections, and the remainder appeared to have had simple colonization. All 19 patients had associated medical conditions or prior therapy. S. marcescens should be…

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Influence of relative humidity on particle size and UV sensitivity of Serratia marcescens and Mycobacterium bovis BCG aerosols

Ko, G., First, M.W., Burge, H.A. (2000) Tubercle and Lung Disease: the Official Journal of the International Union Against Tuberculosis and Lung Disease, 80(4-5), 217-228 SETTING: A study of Serratia marcescens and BCG aerosols. OBJECTIVE: To evaluate the effect of relative humidity (RH) on (1) the particle size and (2) sensitivity of 254nm germicidal ultraviolet (UV) irradiation. METHODS: We built a RH controlled experimental chamber into which bacteria were aerosolized, exposed to varying amounts of UV irradiance over measured time periods, and quantitatively evaluated for viability. Aerosolized Serratia marcescens and…

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