Progression of cannabis withdrawal symptoms in people using medical cannabis for chronic pain

Author: Coughlin, Lara N.; Ilgen, Mark A.; Jannausch, Mary; Walton, Maureen A.; Bohnert, Kipling M. Description: BACKGROUND AND AIMS: Research from cohorts of individuals with recreational cannabis use indicates that cannabis withdrawal symptoms are reported by more than 40% of those using regularly. Withdrawal symptoms are not well understood in those who use cannabis for medical purposes. Therefore, we prospectively examined the stability of withdrawal symptoms in individuals using cannabis to manage chronic pain. DESIGN, SETTING, PARTICIPANTS: Using latent class analysis (LCA) we examined baseline cannabis withdrawal to derive symptom…

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Safety and Efficacy of Medicinal Cannabis in the Treatment of Fibromyalgia: A Systematic Review

Author: Kurlyandchik, Inna; Tiralongo, Evelin; Schloss, Janet Description: Background: Fibromyalgia (FMS) is a complex condition that is characterized by various pain syndromes and fatigue, among other symptoms experienced. Current medical treatment of FMS involves both pharmacological and nonpharmacological approaches, but often with ineffective outcomes. Medicinal cannabis has the potential to be a therapeutic option for patients with FMS due to the positive research in chronic pain management. In addition, it has been found to have fewer adverse effects compared with currently available pain medications. This literature review aims at answering…

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The effectiveness of self-directed medical cannabis treatment for pain

Author: Li, Xiaoxue; Vigil, Jacob M.; Stith, Sarah S.; Brockelman, Franco; Keeling, Keenan; Hall, Branden Description: The prior medical literature offers little guidance as to how pain relief and side effect manifestation may vary across commonly used and commercially available cannabis product types. We used the largest dataset in the United States of real-time responses to and side effect reporting from patient-directed cannabis consumption sessions for the treatment of pain under naturalistic conditions in order to identify how cannabis affects momentary pain intensity levels and which product characteristics are the…

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Atmospheric transport and deposition of microplastics in a remote mountain catchment

Author: Allen, Steve; Allen, Deonie; Phoenix, Vernon R.; Le Roux, Gael; Durantez Jimenez, Pilar; Simonneau, Anaelle; Binet, Stephane; Galop, Didier Description: Plastic litter is an ever-increasing global issue and one of this generation’s key environmental challenges. Microplastics have reached oceans via river transport on a global scale. With the exception of two megacities, Paris (France) and Dongguan (China), there is a lack of information on atmospheric microplastic deposition or transport. Here we present the observations of atmospheric microplastic deposition in a remote, pristine mountain catchment (French Pyrenees). We analysed samples,…

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Microplastic pollution increases gene exchange in aquatic ecosystems

Author: Arias-Andres, Maria; Klumper, Uli; Rojas-Jimenez, Keilor; Grossart, Hans-Peter Description: Pollution by microplastics in aquatic ecosystems is accumulating at an unprecedented scale, emerging as a new surface for biofilm formation and gene exchange. In this study, we determined the permissiveness of aquatic bacteria towards a model antibiotic resistance plasmid, comparing communities that form biofilms on microplastics vs. those that are free-living. We used an exogenous and red-fluorescent E. coli donor strain to introduce the green-fluorescent broad-host-range plasmid pKJK5 which encodes for trimethoprim resistance. We demonstrate an increased frequency of plasmid…

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Up and away: ontogenic transference as a pathway for aerial dispersal of microplastics

Author: Al-Jaibachi, Rana; Cuthbert, Ross N.; Callaghan, Amanda Description: Microplastics (MPs) are ubiquitous pollutants found in marine, freshwater and terrestrial ecosystems. With so many MPs in aquatic systems, it is inevitable that they will be ingested by aquatic organisms and be transferred up through the food chain. However, to date, no study has considered whether MPs can be transmitted by means of ontogenic transference, i.e. between life stages that use different habitats. Here, we determine whether fluorescent polystyrene beads could transfer between Culex mosquito life stages and, particularly, could move…

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Ecotoxicological effects of microplastics on biota: a review

Author: Anbumani, Sadasivam; Kakkar, Poonam Description: The ubiquitous presence of microplastics in the environment has drawn the attention of ecotoxicologists on its safety and toxicity. Sources of microplastics in the environment include disintegration of larger plastic items (secondary microplastics), personal care products like liquid soap, exfoliating scrubbers, and cleaning supplies etc. Indiscriminate usage of plastics and its poor waste disposal management pose serious concern on ecosystem quality at global level. The present review focused on the ecological impact of microplastics on biota at different trophic levels, its uptake, accumulation, and…

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Systematic literature review and metadata analysis of ransomware attacks and detection mechanisms

Author: Maigida, Abdullahi Mohammed; Abdulhamid, Shafi’i Muhammad; Olalere, Morufu; Alhassan, John K.; Chiroma, Haruna; Dada, Emmanuel Gbenga Description: Ransomware is advanced and upgraded malicious software which comes in the forms of Crypto or Locker, with the intention to attack and take control of basic infrastructures and computer systems. The vast majority of these threats are aimed at directly or indirectly making money from the victims by asking for a ransom in exchange for decryption keys. This systematic literature analysed the anatomy of ransomware, including its trends and mode of attacks…

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Ransomware detection using machine learning algorithms

Author: Bae, Seong Il; Lee, Gyu Bin; Im, Eul Gyu Description: The number of ransomware variants has increased rapidly every year, and ransomware needs to be distinguished from the other types of malware to protect users’ machines from ransomware-based attacks. Ransomware is similar to other types of malware in some aspects, but other characteristics are clearly different. For example, ransomware generally conducts a large number of file-related operations in a short period of time to lock or to encrypt files of a victim’s machine. The signature-based malware detection methods, which…

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Understanding the Evolution of Ransomware: Paradigm Shifts in Attack Structures

Author: Zimba, Aaron; Chishimba, Mumbi Description: The devasting effects of ransomware have continued to grow over the past two decades which have seen ransomware shift from just being opportunistic attacks to carefully orchestrated attacks. Individuals and business organizations alike have continued to fall prey to ransomware where victims have been forced to pay cybercriminals even up to $1 million in a single attack whilst others have incurred losses in hundreds of millions of dollars. Clearly, ransomware is an emerging cyber threat to enterprise systems that can no longer be ignored….

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