Author: engeladmin

Henkenius, K., Greene, B.H., Barckhausen, C., Hartmann, R., Marken, M., Kaiser, T., Rehberger, M., Metzelder, S.K., Parak, W.J., Neubauer, A., Brendel, C., Mack, E. (2017) Leukemia Research, 62, 56-63 Primary resistance to induction therapy is an unsolved clinical problem in acute myeloid leukemia (AML). Here we investigated drug resistance in AML at the level of cellular metabolism in order to identify early predictors of therapeutic response. Using extracellular flux analysis, we compared metabolic drug responses in AML cell lines sensitive or resistant to cytarabine or sorafenib after 24h of drug…

Gitter, A.H., Zenner, H.P., Fromter, E. (1986) ORL; Journal for Oto-Rhino-Laryngology and its Related Specialties, 48(2), 68-75 Single outer hair cells from guinea pig cochlea were prepared by microdissection and cultured for several hours in a modified Hanks’ medium. Cells, which were viable, judged by morphological criteria, were investigated with the patch-clamp technique. Membrane potentials up to -70 mV could be measured in the cultured cells. Ion channels were found in the basolateral membrane and in the cuticular region of the hair cells. These ion channels could play an important…

Lee, J.H., Kim, W.H., Danishefsky, S.J. (2009) Tetrahedron Letters, 50(39), 5482-5484 We describe herein the development of efficient and stereoselective synthetic routes to a range of cis- and trans-octalin and hydrindane target compounds. Subject headings: hydrindane; Diels-Alder; cis-octalins; trans-octalins; synthesis Find the full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919757/ Find more like this one (cited by): https://scholar.google.com/scholar?cites=15781382976823970932&as_sdt=1000005&sciodt=0,16&hl=en Type: Journal Article Serial number: 349

Kabalka, G.W., Mereddy, A.R. (2006) Tetrahedron Letters, 47(29), 5171-5172 Microwave irradiation promotes the rapid one-pot synthesis of 2-aminothiazoles formed via the condensation of alpha-bromoketones with thiourea. Subject Headings: Microwave; Aminothiazole; Green chemistry; alpha-Bromoketone; Thiourea Find the full text: https://www.sciencedirect.com/science/article/pii/S0040403906009786 Find more like this one (cited by): https://scholar.google.com/scholar?cites=15084047252456377563&as_sdt=1000005&sciodt=0,16&hl=en Type: Journal Article Serial number: 2550

Hong, C.Y., Overman, L.E. (1994) Tetrahedron Letters, 35(21), 3453-3456 Palladium catalyzed cyclization of hydroisoquinoline diene to afford the pentacyclic opiate is the central step in a new synthesis of opium alkaloids. Subject headings: Opium alkaloids; Palladium; Morphine; Synthesis Find the full text: http://www.sciencedirect.com/science/article/pii/S0040403900732084 Find more like this one (cited by): https://scholar.google.com/scholar?cites=6091943525816174990&as_sdt=1000005&sciodt=0,16&hl=en Type: Journal Article Serial number: 1790

Han, S.-Y., Kim, Y.-A. (2004) Tetrahedron, 60(11), 2447-2467 This review evaluates the advantages, disadvantages, and effectiveness of newly developed peptide coupling reagents used in organic synthesis. Each reagent is classified into one of eight types including phosphonium, uronium, immonium, carbodiimide, imidazolium, organophosphorous, acid halogenating and other coupling reagents, according to the structural similarity. Subject headings: Peptide coupling reagent; Amino acid; Racemisation suppressant; Enantiomeric excess Find the full text: http://www.sciencedirect.com/science/article/pii/S0040402004000651 Find more like this one (cited by): https://scholar.google.com/scholar?cites=4147721855168984242&as_sdt=1000005&sciodt=0,16&hl=en Type: Journal Article Serial number: 2152

Grubbs, R.H. (2004) Tetrahedron, 60(34), 7117-7140 Olefin metathesis has become a tool for synthetic organic and polymer chemists. Well-defined, functional group tolerant catalysts have allowed these advances. A discussion of the evolution of mechanistic understanding and early catalyst developments is followed by a description of recent advances in ruthenium based olefin metathesis catalysts. Catalysts improvements have led to new applications in ring closing metathesis, cross metathesis and materials synthesis. Subject headings: Olefin metathesis; Synthetic organic chemistry; Polymer chemistry; Ruthenium Find the full text: https://www.sciencedirect.com/science/article/pii/S004040200400941X Find more like this one (cited…

Drevermann, B., Lingham, A., Hügel, H., Marriott, P. (2005) Tetrahedron Letters, 46(1), 39-41 Calone 1951®, 7-methyl-benzo[b][1,4]dioxepin-3-one, possesses a strong marine, ozone note with floral nuances and is synthesised via a three-step procedure using microwave irradiation. High yields were obtained, and reaction times reduced to a few minutes, allowing for an efficient and inexpensive synthesis of Calone 1951®. Microwave irradiation has been utilized in a three-step synthetic route to the fragrant compound, 7-methyl-benzo[b][1,4]dioxepin-3-one, commercially known as Calone 1951®. The use of a microwave reactor increases the simplicity and efficiency of the…

Deb, M.L., Bhuyan, P.J. (2005) Tetrahedron Letters, 46(38), 6453-6456 Knoevenagel condensation of various aromatic and heteroaromatic aldehydes with active methylene compounds like malononitrile, ethyl cyanoacetamide, ethyl cyanoacetate, barbituric acids, Meldrum’s acid, dimedone and pyrazolone proceeds smoothly with stirring in an aqueous medium. The reactions occur at room temperature giving excellent yields of the products. The work-up procedure is very simple and the products do not require further purification. Subject headings: Knoevenagel condensation; Barbituric acid; Meldrum’s acid; Malononitrile; Aqueous medium; Uncatalysed reaction Find the full text: https://www.sciencedirect.com/science/article/pii/S004040390501631X Find more like this…

Cokol, N.K., Kaya, S., Balci, M. (2017) Tetrahedron Letters, 58(28), 2732-2735 The regio- and stereoselective synthesis of a new synthon, trans-3,8-dioxatricyclo[3.2.1.02,4]octane-6,7-diamine, from 7-oxabicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate is reported. Transformation of the acid functionalities to acyl azides followed by Curtius rearrangement gave the corresponding trans-diisocyanate, which was reacted with HCl to produce a trans-diamino compound that is a potentially important synthon for the versatile synthesis of aminocyclitols. Subject Headings: Oxabicycloheptene; Aminoinositol; Diacylazide; Curtius rearrangement; Neighboring group participation Find the full text: https://www.sciencedirect.com/science/article/pii/S0040403917307104 Find more like this one (cited by): https://scholar.google.com/scholar?cites=14984188309882251101&as_sdt=1000005&sciodt=0,16&hl=en Type: Journal Article Serial…