The endocrine role of brown adipose tissue: An update on actors and actions
Author: Gavalda-Navarro, Aleix; Villarroya, Joan; Cereijo, Ruben; Giralt, Marta; Villarroya, Francesc Description: In recent years, brown adipose tissue (BAT) has been recognized not only as a main site of non-shivering thermogenesis in mammals, but also as an endocrine organ. BAT secretes a myriad of regulatory factors. These so-called batokines exert local autocrine and paracrine effects, as well as endocrine actions targeting tissues and organs at a distance. The endocrine batokines include peptide factors, such as fibroblast growth factor-21 (FGF21), neuregulin-4 (NRG4), phospholipid transfer protein (PLTP), interleukin-6, adiponectin and myostatin, and…
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