Category: Featured Database

The role of p53 in anti-tumor immunity and response to immunotherapy

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Author: Carlsen, Lindsey; Zhang, Shengliang; Tian, Xiaobing; De La Cruz, Arielle; George, Andrew; Arnoff, Taylor E.; El-Deiry, Wafik S. Description: p53 is a transcription factor that regulates the expression of genes involved in tumor suppression. p53 mutations mediate tumorigenesis and occur in approximately 50% of human cancers. p53 regulates hundreds of target genes that induce various cell fates including apoptosis, cell cycle arrest, and DNA damage repair. p53 also plays an important role in anti-tumor immunity by regulating TRAIL, DR5, TLRs, Fas, PKR, ULBP1/2, and CCL2; T-cell inhibitory ligand PD-L1;…

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Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization

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Author: Graves, Bradford; Thompson, Thelma; Xia, Mingxuan; Janson, Cheryl; Lukacs, Christine; Deo, Dayanand; Di Lello, Paola; Fry, David; Garvie, Colin; Huang, Kuo-Sen; Gao, Lin; Tovar, Christian; Lovey, Allen; Wanner, Jutta; Vassilev, Lyubomir T. Description: Activation of p53 tumor suppressor by antagonizing its negative regulator murine double minute (MDM)2 has been considered an attractive strategy for cancer therapy and several classes of p53-MDM2 binding inhibitors have been developed. However, these compounds do not inhibit the p53-MDMX interaction, and their effectiveness can be compromised in tumors overexpressing MDMX. Here, we identify small…

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The state of the bats in North America

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Author: Adams, Amanda M.; Trujillo, Luis A.; Campbell, C. J.; Akre, Karin L.; Arroyo-Cabrales, Joaquin; Burns, Leanne; Coleman, Jeremy T. H.; Dixon, Rita D.; Francis, Charles M.; Gamba-Rios, Melquisedec; Kuczynska, Vona; McIntire, Angie; Medelli­n, Rodrigo A.; Morris, Katrina M.; Ortega, Jorge; Reichard, Jonathan D.; Reichert, Brian; Segers, Jordi L.; Whitby, Michael D.; Frick, Winifred F. Description: The world’s rich diversity of bats supports healthy ecosystems and important ecosystem services. Maintaining healthy biological systems requires prompt identification of threats to biodiversity and immediate action to protect species, which for wide-ranging bat…

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Monarch Butterflies in Western North America: A Holistic Review of Population Trends, Ecology, Stressors, Resilience and Adaptation

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Author: James, David G. Description: Monarch butterfly populations in western North America suffered a substantial decline, from millions of butterflies overwintering in California in the 1980s to less than 400,000 at the beginning of the 21st century. The introduction of neonicotinoid insecticides in the mid-1990s and their subsequent widespread use appears to be the most likely major factor behind this sudden decline. Habitat loss and unfavorable climates (high temperatures, aridity, and winter storms) have also played important and ongoing roles. These factors kept overwintering populations stable but below 300,000 during…

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Temperature is positively associated with tree mortality in California subalpine forests containing whitebark pine

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Author: Young, Derek J. N.; Slaton, Michèle R.; Koltunov, Alexander Description: Whitebark pine (Pinus albicaulis Engelm.) is a keystone high-elevation tree species occurring across much of western North America, yet it has been listed as threatened under the US Endangered Species Act due to rapid population declines and extensive ongoing pressures from white pine blister rust (Cronartium ribicola), mountain pine beetle (Dendroctonus ponderosae), and increasing temperature and aridity associated with climate change. Past research has shown that whitebark pine mortality is more likely in hotter and drier sites, but no…

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Trends in the Diels–Alder reaction in polymer chemistry

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Author: Briou, Benoit; Ameduri, Bruno; Boutevin, Bernard Description: The Diels–Alder (DA) reaction is regarded as quite a useful strategy in organic and macromolecular syntheses. The reversibility of this reaction and the advent of self-repair technology, as well as other applications in controlled macromolecular architectures and crosslinking, have strongly boosted the research activity, which is still attracting a huge interest in both academic and industrial research. The DA reaction is a simple and scalable toolbox. Though it is well-established that furan/maleimide is the most studied diene/dienophile couple, this perspective article reports…

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Insight into a natural Diels-Alder reaction from the structure of macrophomate synthase

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Author: Ose, Toyoyuki; Watanabe, Kenji; Mie, Takashi; Honma, Mamoru; Watanabe, Hiromi; Yao, Min; Oikawa, Hideaki; Tanaka, Isao Description: The Diels–Alder reaction, which forms a six-membered ring from an alkene (dienophile) and a 1,3-diene, is synthetically very useful for construction of cyclic products with high regio- and stereoselectivity under mild conditions. It has been applied to the synthesis of complex pharmaceutical and biologically active compounds. Although evidence on natural Diels–Alderases has been accumulated in the biosynthesis of secondary metabolites, there has been no report on the structural details of the natural Diels–Alderases….

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How to rescue biofuels from a sustainable dead end

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Author: Fairley, Peter Description: Russia’s invasion of Ukraine squeezed global oil supplies and inflation increased prices at the pumps. Although petrol prices then started to fall after several months, the situation delivered a powerful reminder of the world’s dependence on fossil fuels … Subject headings: Biofuels; Biotechnology; Sustainable Development; Agriculture; Environmental sciences; Sustainability Publication year: 2022 Journal or book title: Nature Volume: 611 Issue: 7936 Pages: S15-S17 Find the full text: https://www.strategian.com/fulltext/Fairley2022.pdf Find more like this one (cited by): https://scholar.google.com/scholar?cites=204846560647340686&as_sdt=1000005&sciodt=0,16&hl=en Serial number: 4007

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How Many People Were Killed by Windblown Dust Events in the United States?

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Author: Tong, D.; Feng, Irene Y.; Gill, Thomas E.; Schepanski, K.; Wang, J. Description: Windblown dust events, including dust storms and smaller blowing dust events, pose severe risks to public health and transportation safety. In the United States, the statistics of fatalities caused by dust events remains elusive. We developed a new dataset by merging dust fatality data from NOAA Storm Events Database and the Department of Transportation Fatality Analysis Reporting System (FARS). There was a total of 232 deaths from windblown dust events from 2007 to 2017. This number…

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Protection of the human gene research literature from contract cheating organizations known as research paper mills

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Author: Byrne, Jennifer A.; Park, Yasunori; Richardson, Reese A. K.; Pathmendra, Pranujan; Sun, Mengyi; Stoeger, Thomas Description: Human gene research generates new biology insights with translational potential, yet few studies have considered the health of the human gene literature. The accessibility of human genes for targeted research, combined with unreasonable publication pressures and recent developments in scholarly publishing, may have created a market for low-quality or fraudulent human gene research articles, including articles produced by contract cheating organizations known as paper mills. This review summarises the evidence that paper mills…

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