Effects of low doses of mifepristone on human embryo implantation process in a three-dimensional human endometrial in vitro co-culture system
Author: Boggavarapu, N.R.; Berger, C.; von Grothusen, C.; Menezes, J.; Gemzell-Danielsson, K.; Lalitkumar, P.G.L. Description: OBJECTIVES: We wanted to explore the effects of two different low doses (0.5muM and 0.05muM) of mifepristone, exposed during the receptive period, on the human embryo implantation process, using a well-established three-dimensional in vitro cell culture model, specifically developed to study this process. METHODS: An in vitro three-dimensional cell culture model was constructed using human endometrial cells isolated from the endometrium of proven fertile women, collected on cycle day LH+4. After 5 days of culture,…
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