Mitomycin C induces apoptosis via Fas/FasL dependent pathway and suppression of IL-18 in cervical carcinoma cells
Author: Kang, Yun Hee; Lee, Kyung-Ae; Ryu, Chun Jeih; Lee, Hee-Gu; Lim, Jong-Seok; Park, Sue Nie; Paik, Sang-Gi; Yoon, Do-Young Description: Mitomycin C (MMC) is used fairly widely as an anticancer drug, as it possesses mechanisms of action which are preferable to other chemotherapeutic compounds, including cisplatin, docetaxel, and lovastatin. In the previous study, we established the RSV-luc promoter analysis system, which is used to screen drugs against cervical carcinomas caused by HPV infection. We then demonstrated the repression of HPV E6-activated RSV promoter activity by anticancer agents such as…
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