Human telomere length is chromosome end-specific and conserved across individuals
Author: Karimian, Kayarash; Groot, Aljona; Huso, Vienna; Kahidi, Ramin; Tan, Kar-Tong; Sholes, Samantha; Keener, Rebecca; McDyer, John F.; Alder, Jonathan K.; Li, Heng; Rechtsteiner, Andreas; Greider, Carol W. Description: Short telomeres cause age-related disease, and long telomeres contribute to cancer; however, the mechanisms regulating telomere length are unclear. We developed a nanopore-based method, which we call Telomere Profiling, to determine telomere length at nearly single-nucleotide resolution. Mapping telomere reads to chromosome ends showed chromosome end-specific length distributions that could differ by more than six kilobases. Examination of telomere lengths in…
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