Author: Steiger, A.; Dresler, M.; Schussler, P.; Kluge, M.
Description: Ghrelin acts as a neuropeptide. It participates in sleep-wake regulation. After systemic ghrelin treatment nonREM sleep is promoted in male humans and mice. This effect is influenced by gender, time of administration and depression. Ghrelin does not modulate sleep in healthy women and during the early morning in male subjects. In depressed women REM sleep is diminished after ghrelin. In elderly men and depressed men sleep promotion by ghrelin was preserved. In rats after central ghrelin feeding and wakefulness increased. The nocturnal secretion pattern of cortisol, GH, LH, FSH and hypothalamo-pituitary-thyroid hormones are influenced by ghrelin. Furthermore ghrelin appears to be related to memory and to be involved in the pathophysiology of CNS disorders, particularly depression.
Subject Headings: Animals; Depression/metabolism/physiopathology; Ghrelin/metabolism; Humans; Memory/physiology; Mental Health; Nervous System Diseases/metabolism/physiopathology; Sex Characteristics; Sleep/physiology
Keywords: Ghrelin in mental health, sleep, memory
Publication year: 2011
Journal or book title: Molecular and Cellular Endocrinology
Volume: 340
Issue: 1
Pages: 88-96
Find the full text : https://www.sciencedirect.com/science/article/pii/S0303720711001213
Find more like this one (cited by): https://scholar.google.com/scholar?cites=11577820114912078858&as_sdt=1000005&sciodt=0,16&hl=en
Type: Journal Article
Serial number: 2753