The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia
Author: Song, K.; Wang, H.; Kamm, G.B.; Pohle, J.; Reis, F. de C.; Heppenstall, P.; Wende, H.; Siemens, J. Description: Body temperature homeostasis is critical for survival and requires precise regulation by the nervous system. The hypothalamus serves as the principal thermostat that detects and regulates internal temperature. We demonstrate that the ion channel TRPM2 [of the transient receptor potential (TRP) channel family] is a temperature sensor in a subpopulation of hypothalamic neurons. TRPM2 limits the fever response and may detect increased temperatures to prevent overheating. Furthermore, chemogenetic activation and…
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