Author: engeladmin

Author: Senft, Daniela; Qi, Jianfei; Ronai, Ze’ev A. Description: The cellular response to external stress signals and DNA damage depends on the activity of ubiquitin ligases (E3s), which regulate numerous cellular processes, including homeostasis, metabolism and cell cycle progression. E3s recognize, interact with and ubiquitylate protein substrates in a temporally and spatially regulated manner. The topology of the ubiquitin chains dictates the fate of the substrates, marking them for recognition and degradation by the proteasome or altering their subcellular localization or assembly into functional complexes. Both genetic and epigenetic alterations…

Author: Leach, Mark K.; Givnish, Thomas J. Description: Recensuses of 54 Wisconsin prairie remnants showed that 8 to 60 percent of the original plant species were lost from individual remnants over a 32- to 52-year period. The pattern of species loss was consistent with the proposed effects of fire suppression caused by landscape fragmentation. Short, small-seeded, or nitrogen-fixing plants showed the heaviest losses, as did species growing in the wettest, most productive environments. The interruption of landscape-scale processes (such as wildfire) by fragmentation is an often overlooked mechanism that may…

Author: Lee, Sooncheol; Hoyt, Stephanie; Wu, Xiaoyun; Garvie, Colin; McGaunn, Joseph; Shekhar, Mrinal; Totzl, Marcus; Rees, Matthew G.; Cherniack, Andrew D.; Meyerson, Matthew; Greulich, Heidi Description: Velcrin compounds kill cancer cells expressing high levels of phosphodiesterase 3A (PDE3A) and Schlafen family member 12 (SLFN12) by inducing complex formation between these two proteins, but the mechanism of cancer cell killing by the PDE3A-SLFN12 complex is not fully understood. Here, we report that the physiological substrate of SLFN12 RNase is tRNALeu(TAA). SLFN12 selectively digests tRNALeu(TAA), and velcrin treatment promotes the cleavage of…

Author: Triandis, Harry C.; Chen, Xiao Ping; Chan, Darius K.-S. Description: This article presents a method that uses scenarios for the measurement of horizontal (H) and vertical (V) individualism (I) and collectivism (C) across cultures, with university samples. The scenarios were developed by using focus groups, to cover a wide range of social situations often found among university students. Graduate student judges indicated which responses to each scenario represented HI, VI, HC, or VC judgments. When the judges did not agree on these judgments, the scenarios were eliminated. Scenarios that…

Author: Mann, Leon; Radford, Mark; Burnett, Paul; Ford, Steve; Bond, Michael; Leung, Kwok; Nakamura, Hiyoshi; Vaughan, Graham; Yang, Kuo-Shu Description: The Melbourne Decision Making Questionnaire (Mann, Burnett, Radford, & Ford, 1997) measures self‐reported decision‐making coping patterns. The questionnaire was administered to samples of University students in the US ( N = 475), Australia ( N = 262), New Zealand ( N = 260), Japan ( N = 359), Hong Kong ( N = 281), and Taiwan ( N = 414). As predicted, students from the three Western, individualistic cultures (US,…

Author: Wong, Samuel Yeung-Shan; Chan, Frank Wan-Kin; Wong, Rebecca Lai-Ping; Chu, Ming-Chi; Kitty Lam, Yu-Yuk; Mercer, Stewart W.; Ma, S. Helen Description: OBJECTIVES: Research suggests that an 8-week Mindfulness-Based Stress Reduction (MBSR) program (a structured form of meditation) might be effective in the treatment of various health problems including chronic pain. Our objective was to compare the clinical effectiveness of the MBSR program with a multidisciplinary pain intervention (MPI) program in terms of pain intensity, pain-related distress, quality of life, and mood in patients with chronic pain. METHODS: A randomized,…

Author: Ohbuchi, Ken-Ichi; Fukushima, Osamu; Tedeschi, James T. Description: Americans (individualists) and Japanese (collectivists) were asked to rate their conflict experiences in terms of goal orientation, goal attainment, tactics, and outcome satisfaction. Individualists preferred assertive tactics, whereas collectivists preferred avoidance tactics. The results regarding goal orientation showed that individualists were strongly oriented toward achieving justice, but collectivists were more motivated by a concern for relationships with others. The finding that attainment of a justice goal did not strongly satisfy the Americans suggests that justice is an instrumental value and not…