Tag: Humans

Clinical Pharmacokinetics of Semaglutide: A Systematic Review

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Author: Yang, XD; Yang, YY Description: PURPOSE: The aim of this review was to provide all the pharmacokinetic data for semaglutide in humans concerning its pharmacokinetics after subcutaneously and oral applications in healthy and diseased populations, to provide recommendations for clinical use. METHODOLOGY: The PubMed and Embase databases were searched to screen studies associated with the pharmacokinetics of semaglutide. The pharmacokinetic parameters included area under the curve plasma concentrations (AUC), maximal plasma concentration (C(max)), time to C(max), half-life (t(1/2)), and clearance. The systematic literature search retrieved 17 articles including data…

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Why Hybrid Intelligence Is the Future of Human-AI Collaboration

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Author: Walther, Cornelia C. Description: Hybrid intelligence combines the computational strengths of artificial intelligence with the holistic comprehension of natural intelligence, leading to more sustainable, creative, and trustworthy results. Natural intelligence offers a holistic understanding of human complexity and the consequences of AI on society. Organizations can curate hybrid intelligence by investing in algorithmic fluency and humanistic insights. Subject headings: Hybrid intelligence; Artificial intelligence; Natural intelligence Publication year: 2025 Journal or book title: Knowledge at Wharton Find the full text: https://knowledge.wharton.upenn.edu/article/why-hybrid-intelligence-is-the-future-of-human-ai-collaboration/ Find more like this one (cited by): https://scholar.google.com/scholar?cites=8072983520551362401&as_sdt=1000005&sciodt=0,16&hl=en Serial…

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Winners and losers of generative AI: Early Evidence of Shifts in Freelancer Demand

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Author: Teutloff, Ole; Einsiedler, Johanna; Kassi, Otto; Braesemann, Fabian; Mishkin, Pamela; del Rio-Chanona, R. Maria Description: We examine how ChatGPT has changed the demand for freelancers in jobs where generative AI tools can act as substitutes or complements to human labor. Using BERTopic we partition job postings from a leading online freelancing platform into 116 fine-grained skill clusters and with GPT-4o we classify them as substitutable, complementary or unaffected by LLMs. Our analysis reveals that labor demand increased after the launch of ChatGPT, but only in skill clusters that were…

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Mercury pollution sources and cycle

Mercury as a global pollutant: sources, pathways, and effects

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Author: Driscoll, Charles T.; Mason, Robert P.; Chan, Hing Man; Jacob, Daniel J.; Pirrone, Nicola Description: Mercury (Hg) is a global pollutant that affects human and ecosystem health. We synthesize understanding of sources, atmosphere-land-ocean Hg dynamics and health effects, and consider the implications of Hg-control policies. Primary anthropogenic Hg emissions greatly exceed natural geogenic sources, resulting in increases in Hg reservoirs and subsequent secondary Hg emissions that facilitate its global distribution. The ultimate fate of emitted Hg is primarily recalcitrant soil pools and deep ocean waters and sediments. Transfers of…

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Ways to play with cats (in this study)

Effects of the characteristic temperament of cats on the emotions and hemodynamic responses of humans

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Author: Nagasawa, Takumi; Ohta, Mitsuaki; Uchiyama, Hidehiko Description: Cats positive effects on their owners’ physiological and psychological health, including improved mood and activation of the human prefrontal cortex and inferior frontal gyrus in the brain. However, the association between the health benefits provided by cat ownership and the characteristic behaviors and reactions of cats is unclear. We recruited 29 participants to measure human prefrontal cortex activity, using functional near-infrared spectroscopy, during interactions with a cat. After the experiments, participants subjectively responded to a questionnaire regarding success rates for interactions with…

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Cat-human activities related to human well-being

Cat-human related activities associated with human well-being

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Author: Ravenscroft, Samantha J.; Barcelos, Ana Maria; Mills, Daniel S. Description: Besides inconsistent evidence relating to the mental health benefits of pet ownership, there is a specific lack of data in relation to cat ownership. Research in this field frequently fails to consider the effect of specific cat-human relationships or activities that might impact owner well-being. This study aimed to identify and address this gap by examining the activities associated with owning a cat that were perceived by owners to impact on their well-being. Twenty cat owners (18 to 74…

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Cat attachment and effect on human health

Does cat attachment have an effect on human health? A comparison between owners and volunteers

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Author: Dinis, Filipa A. B. S. G.; Martins, Thais Lima Fernandes Description: Cat owners and volunteers from a rehoming centre were given the Lexington Attachment to Pet Scale (LAPS) questionnaire to assess their level of attachment to their own or rescue cats. In addition, heart rate and blood pressure were measured 10 minutes before, during, and after spending time with the cats. Consistent with other studies, the results here show that spending time with a cat can reduce heart rate and both systolic and diastolic blood pressure, and that this…

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Development and Clinical Application of Phosphorus-Containing Drugs

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Author: Yu, Hanxiao; Yang, He; Shi, Enxue; Tang, Wenjun Description: Phosphorus-containing drugs belong to an important class of therapeutic agents and are widely applied in daily clinical practices. Structurally, the phosphorus-containing drugs can be classified into phosphotriesters, phosphonates, phosphinates, phosphine oxides, phosphoric amides, bisphosphonates, phosphoric anhydrides, and others; functionally, they are often designed as prodrugs with improved selectivity and bioavailability, reduced side effects and toxicity, or biomolecule analogues with endogenous materials and antagonistic endoenzyme supplements. This review summarized the phosphorus-containing drugs currently on the market as well as a few…

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Role of sulphur-heterocycles in medicinal chemistry: An update

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Author: Pathania, Shelly; Narang, Raj Kumar; Rawal, Ravindra K. Description: From many decades, S-heterocycles have maintained their status as an important part and core of FDA approved drugs and medicinally active compounds. With exhaustive exploration of nitrogen heterocycles in medicinal chemistry, researchers have shifted their interest towards other heterocycles, especially, S-heterocycles. Thus several attempts have been made to synthesize a variety of new sulphur containing compounds with high medicinal value and low toxicity profile, in comparison to previous N-heterocycles. Till today, S-heterocycle containing compounds have been largely reported as anticancer,…

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The Presence of Bacteriophages in the Human Body: Good, Bad or Neutral?

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Author: Lusiak-Szelachowska, Marzanna; Weber-Dabrowska, Beata; Zaczek, Maciej; Borysowski, Jan; Gorrski, Andrzej Description: The presence of bacteriophages (phages) in the human body may impact bacterial microbiota and modulate immunity. The role of phages in human microbiome studies and diseases is poorly understood. However, the correlation between a greater abundance of phages in the gut in ulcerative colitis and diabetes has been suggested. Furthermore, most phages found at different sites in the human body are temperate, so their therapeutic effects and their potential beneficial effects remain unclear. Hence, far, no correlation has…

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