Is artificial intelligence a good servant but a bad master?

Author: Lakhtakia, Akhlesh; Lakhtakia, Natalya S. Description: Artificial intelligence (AI) is rapidly moving from a specialized research topic into a widely deployed general-purpose technology, driven by advances in transformer-based architectures, convincing enough productivity gains, large private investment, geopolitical competition, and expanding educational adoption. AI comprises two distinct sets of methodologies: (i) predictive AI, which is grounded in statistical inference and aims to model measurable physical reality, and (ii) generative AI, which produces plausible synthetic content without intrinsic verification against physical reality. Whereas predictive AI can strengthen human decision-making through rigorously…

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The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia

Author: Song, K.; Wang, H.; Kamm, G.B.; Pohle, J.; Reis, F. de C.; Heppenstall, P.; Wende, H.; Siemens, J. Description: Body temperature homeostasis is critical for survival and requires precise regulation by the nervous system. The hypothalamus serves as the principal thermostat that detects and regulates internal temperature. We demonstrate that the ion channel TRPM2 [of the transient receptor potential (TRP) channel family] is a temperature sensor in a subpopulation of hypothalamic neurons. TRPM2 limits the fever response and may detect increased temperatures to prevent overheating. Furthermore, chemogenetic activation and…

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